- Amy Adams ("Doubt" and "Enchanted"), is appealing as spunky aviatrix Amelia Earhart.
- Robin Williams ("Mrs. Doubtfire" and "Patch Adams"), once again makes a bully Teddy Roosevelt.
- Owen Wilson ("Shanghai Noon" and "Starsky and Hutch"), repeats his miniature cowboy action figure, Jedediah Smith, originated for the first "Night in a Museum" outing.
- Steve Coogan ("Hamlet 2" and "Tropic Thunder") is another miniature action figure, Jedediah's sidekick, Roman soldier Octavius.
- Christopher Guest ("Spinal Tap" and "Mrs. Henderson Presents") resents that his character is called Ivan the Terrible; he thinks it should be Ivan the Awesome!
- Hank Azaria ("American Sweethearts" and "The Birdcage") is villainous as a lisping Egyptian pharaoh Kamunrah, and then proceeds to show us his stuff as a voice actor (LOTS of TV characters), by voicing both statues, The Thinker and Abe Lincoln.
- Ricky Gervais ("Extras" and "Stardust") comes back as a museum official who resents any and all changes to his beloved New York Museum of Natural History.
- Keith Powell (lots of TV) is rock solid as a Tuskegee Airman who commiserates with Earhart, "They didn't think WE could fly, either!"
Because I love history, this was far more interesting to me than the first "Museum" offering, and the enormous Smithsonian makes a much bigger playpen for our boy wonder, Mr. Stiller. I had a good time!